Factors immediately involved in the

Factors immediately involved in the caries process, either as ‘attack’ or ‘defence’ mechanisms, at the site of the development of the lesion. To this group, on the attack side, the dental plaque, the presence of various specific microorganisms in the plaque (including mutans streptococci) and the diet can be included. On the defence side for example, the salivary protective systems and the fluoride exposure can be incorporated. These are key factors determining if a caries lesion will occur or not, at the specific tooth surface they are interacting.